[Long-term results of surgery and preoperative hypoxyradiotherapy for colorectal cancer].

Combined treatment for colorectal cancer involving preoperative hypooxyradiotherapy was used to boost targeted irradiation of tumor cells. End results were significantly improved due to the decrease in the number of distant metastases even in cases of poor prognosis because of lymph node involvement.

[Problems of radiation therapy of patients with malignant tumors and modern ways of resolving them].

At the present stage of radiation oncology, treatment successes are mainly determined by improvement of multimodality therapy that utilizes benefits of each modality in individual patients. Radiotherapy is mostly empiric, as demonstrated by dose fractionation. Its significance in many situations is underestimated, which leads to unreasonably excessive irradiation or, vice versa, to its unreasonable refusal.

[Conservative therapy for early-stage breast cancer].

An evaluation of the data on the treatment of 298 cases of breast cancer (stages IIa and IIb) showed that a reduced frequency of loco-regional recurrences, after post-operative irradiation as a component of conservative therapy, was followed by improvement in quality of life. This was particularly apparent in patients with pT2pN1 tumors. It was also found that after extended dissection of axillary lymph nodes at all three levels, a dose of 50 Gy was sufficient without additional irradiation of the cicatrix.

[Metastatic lung tumors in children (clinical course, diagnosis, prognosis)].

According to data available at the Institute (1985-1999, approx. 1,200 patients), the lung is the most frequent site of cancer dissemination (up to 75%). Such most frequent pediatric children tumors as Wilms' tumor, neuroblastoma, rhabdosarcoma, osteogenic sarcoma and that of Ewing disseminate to lung in 85%, particularly, at advanced stages.