[The use of a method of estimating the count of viable Rickettsia prowazekii for the screening of efficacious antibiotics].

The possibility of the evaluation of antirickettsial activity of chemopreparations, both in vitro (by the inhibition of hemolytic activity) and in vivo (under the conditions of experimental pulmonary rickettsiosis in mice), with the use of the rapid method for the determination of the number of metabolically active rickettsiae is shown. The proposed approach may be used in the complex of mutually complementary methods for the screening of antirickettsial preparations.

[Effect of polyunsaturated phosphatidylcholine on the activity of antioxidant and lipolytic enzymes in alimentary hypercholesterolemia in irradiated rats].

A high-cholesterol diet containing 3.5% cholesterol, 0.2% methyl thiouracil and 20% of heated sunflower-seed oil caused an increase in the content of cholesterol, triacylglycerols, diene conjugates and in the activity of phospholipase A2 in rat liver and of serum total cholesterol and cholesterol of low density lipoproteins, and a decrease in the activity of hepatic cholesterol esterase, in the fractional activity of lecithin:cholesterol acetyl transferase (LCAT), in the activity of the enzymes involved in the lipolytic transformation of lipoproteins and in the serum levels of very low density lipoprotein cholesterol.