[Effect of met enkephalin, leu enkephalin and their retro analogs on the lactotropic function of the pituitary gland].

When administered subcutaneously to male rats, the novel peptides retromet-enkephalin and retro-leu-enkephalin stimulated prolactin (PRL) release less powerfully than morphine but somewhat greater than met-enkephalin. Leu-enkephalin did not affect PRL secretion in vivo. Neither morphine nor any of opioid peptides under study were able to stimulate basal or the dopamine-inhibited PRL release from cultured adenohypophyseal cells of male rats.

[Biological properties of 11-deoxyprostaglandin E1].

A study was made of 11-desoxyprostaglandin E1 (11-desoxy-PGE1) effect on bronchial resistance, gastric secretion, indomethacin-induced ulcer in rats and adrenalin-produced lipolysis in rat epididymal adipose tissue in vitro. The drug exerted dose-dependent bronchodilator effect in doses of 1 to 100 micrograms/kg. ED50 was 18.