[Microprocessor controllers in portable ultrasonic diagnostic units].

Application possibilities of the unified microprocessor module, which allows one to widen ultrasound diagnostic unit's parameters, have been considered herein: i.e. maintenance of the unit's functional keyboard, output of the alphabet-digital information, cursor, markers on the monitor screens, monitoring of the movement of markers and cursor all around the screen, calculation of the distance between them, monitoring of the unit's modes, calculations of the table data based parameters and established formulas.

[Monoclonal antibodies to antigens found on the neutrophils, activated T-lymphocytes and blast cells in human acute leukemia].

Two hybridomas secreting mouse cytotoxic monoclonal antibodies to in vivo and in vitro activated human T-lymphocyte and neutrophil surface membrane antigenic determinants have been produced. One of these monoclonal antibodies (Ta/H-2) appeared to be also specifically reactive to blast cells in the majority of non-T-non-B and T acute lymphoblastic leukemia patients.

[Strain of Yoshida sarcoma with induced pafencil resistance].

Pafencyl, a new antineoplastic drug, approved for use in the USSR, was administered orally to Wistar rats bearing subcutaneous Ioshida's sarcomas (during 5 days, 1 to 10 mg/kg bw). Administration of the drug during several days induced drug resistance. Since the 28th transplant generation accompanied by pafencyl administration drug resistance became stable and the maximal tolerable dose (MTD) 40 mg/kg, which causes regression of the sensitive strain, was ineffective.

[Induction of drug resistance to sarcolysine in plasmacytoma line MORC/406].

A sarcolysine-resistant strain of mouse plasmacytoma MOPC/406 was obtained in experiments on 250 BALB/c mice. The initial plasmacytoma strain is highly sensitive to sarcolysine. When administered in doses of 10 and 5 mg/kg it increases the lifespan up to 50 days (the observation period).