[The activity of the neurohumoral regulatory systems, the status of the electrolyte balance and the clinical efficacy of Renitec in hypertension patients].

Hypotensive effect of renitek (enalapril maleate) was assessed by activity of some neuroregulation systems and electrolyte balance in 16 patients with essential hypertension (EH). Maximal time of treatment for the assessment was 14 days. Renitek in a single dose 20-40 mg/day produced a response in 80% of EH stage II patients with low activity of plasma renin (PR).

[The antihypertensive activity of benazepril in the long-term treatment of hypertension patients and its effect on adrenal cortical function].

Changes in arterial hypertension, heart rate and adrenocortical hormones (11-OCS, aldosteron, progestins) in the blood and 24-h urine were followed up in the course of 24-week use of angiotensin-converting enzyme inhibitor benazepril (10-20 mg once a day) in 24 patients with mild and moderate essential hypertension (EH) included in a placebo-controlled randomized study. A 2 and 24-week antihypertensive response was achieved in 75 and 71% of patients, respectively. 24-h urinary excretion of corticosteroids before the treatment was increased.