Publications by authors named "G Tuncman"
Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections, though the underlying mechanisms remain unknown. Our study highlights fatty acid-binding protein 4 (FABP4), a key regulator of metabolic dysfunction and inflammation, as a modulator of SARS-CoV-2 pathogenesis, correlating strongly with disease severity in COVID-19 patients.
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- Obesity-related airway disease is a poorly understood condition that differs from traditional asthma and is linked to a hormone called FABP4, which plays a key role in the disease's development.
- Research using mouse models and human samples reveals that obesity disrupts lipid metabolism and immune responses in the lungs, activating stress responses and impacting important genes involved in lung function.
- Targeting circulating FABP4 with antibodies shows promise as a new treatment strategy, emphasizing the need to address this distinctive condition referred to as fatty lung disease associated with obesity.
Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains unclear. Increased connexin 43 (Cx43)-mediated intercellular communication has been implicated in tissue-adaptive and -maladaptive response to various chronic stresses.
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