Trained immunity causes myeloid cell hypercoagulability.

The pathogenic basis for increased thrombotic risk in individuals with inflammatory diseases is poorly understood. Myeloid cell "trained immunity" describes persistent innate immune cell memory arising from prior exposure to an inflammatory stimulus, leading to an enhanced immune response to subsequent unrelated stimuli. We identify enhanced myeloid cell prothrombotic activity as a maladaptive consequence of trained immunity.

Tissue factor-dependent colitogenic CD4 T cell thrombogenicity is regulated by activated protein C signalling.

Patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE), but the underlying mechanistic basis remains poorly defined. Here, we find that colitogenic CD4 T cells express tissue factor (TF) and promote rapid TF-dependent plasma thrombin generation. TFCD3CD4 T cells are present in both the colons of mice with experimental colitis and blood and colonic tissue from patients with IBD.

Thermodynamic Properties of γ- and δ-Lactones: Exploring Alkyl Chain Length Effect and Ring-Opening Reactions for Green Chemistry Applications.

An extensive thermochemical study of γ-undecanolactone and δ-undecanolactone has been developed using two complementary calorimetric techniques. The combustion energy of each compound was determined by static-bomb combustion calorimetry, and the corresponding enthalpy of vaporization was determined by high-temperature Calvet microcalorimetry, in which both properties of each compound are reported at = 298.15 K.

Mars Mission Communication Delays and Impact on Mission Controller Performance, Workload, and Stress.

Background: Mission Controllers (MCs) are the main point of contact for space crews and are vital for successful human spaceflight. On a mission to Mars, there will be as long as 22-min one-way communication delays between the ground and the crew, causing major changes to current communication infrastructures.

Methods: This exploratory study assessed the impact of a 20-min one-way communication delay on MCs' task performance, workload, and stress levels under nominal and off-nominal conditions, conducted during a 21-d analog mission.

A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom.

Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP antivenom, especially against neurotoxic elapid venoms. To test this, 25 horses that have been regularly immunized to produce this antivenom were reimmunized with an immunogen containing 22 venoms from various snake species from the genera , , , and both spitting and non-spitting . The plasma collected from these horses was processed using the caprylic acid method to produce an industrial-scale freeze-dried antivenom.