Publications by authors named "G Tsongalis"
Article Synopsis
- Head and neck cancer (HNC) is a growing health issue in Rwanda, with a study analyzing data from 1001 patients revealing that 82% had squamous cell carcinoma and a mean age of diagnosis at 51.1 years, predominantly in males.
- The study utilized p16 immunohistochemistry to assess HPV prevalence, finding that 22% of cases were p16-positive, with 19% testing positive for HPV, particularly HPV16.
- It concluded that there is an urgent need for improved cancer testing and data collection in Rwanda to better understand and combat HNC, especially focusing on oropharyngeal cases and associated risk factors.
Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.
Victoria M Jones Lester D R Thompson Jason R Pettus Donald C Green Joel A Lefferts Gregory J Tsongalis
Head Neck Pathol
October 2024
Article Synopsis
- Mesenchymal neoplasms in the nasal cavity, such as angioleiomyoma (AL) and angiomyolipoma (AML), are rare tumors that involve vascular, smooth muscle, and adipocytic components, with unclear classifications as hamartomas or true neoplasms due to limited genetic research.
- A multi-institutional retrospective study collected data on 15 nasal cavity lesions, primarily affecting older males with obstructive symptoms, and analyzed tissue samples for genetic features.
- The study discovered that most cases had a high proportion of smooth muscle, with some showing additional components like blood vessels and fatty tissue, while all lesions were positive for smooth muscle markers, indicating their muscular origin.
Article Synopsis
- Deep learning applied to spatial transcriptomics (ST) helps understand how gene expression relates to tissue structure, allowing for large-scale studies that are more cost-effective compared to traditional methods.
- Most research has focused on improving algorithms, but there’s a lack of understanding about how tissue preparation and imaging quality impact model training, which is crucial for clinical use.
- A new enhanced tissue processing and imaging protocol was developed to improve model performance in predicting gene expression, showing promising results when compared to traditional methods using a study involving colorectal cancer patients.
Purpose: Mesenchymal neoplasms composed of vascular, smooth muscle, and adipocytic components are uncommon in the nasal cavity. While angioleiomyoma (AL) is a smooth muscle tumor in the Head & Neck WHO classification, it is considered of pericytic origin in the Skin as well as Soft Tissue and Bone classifications. For nasal AL with an adipocytic component, the terms AL with adipocytic differentiation and angiomyolipoma (AML) have been applied, among others.
View Article and Find Full Text PDFArticle Synopsis
- * A pilot program was launched where pharmacists reviewed genetic test results, provided drug-dosing advice, and documented interactions in patient records, which were shared with oncologists.
- * Results showed that out of 71 patients, 21 had actionable genetic variants, leading to dose changes in five patients, demonstrating the potential of pharmacist involvement in personalized medicine.