Protective role of zinc-metallothionein on DNA damage in vitro by ferric nitrilotriacetate (Fe-NTA) and ferric salts.

Oxidative DNA damage can be caused by radicals generated by transitional metals like iron in Fenton reaction. Metallothionein (MT) may play an important role in preventing oxidative DNA damage. Therefore, after comparing the effects of ferric salts (Fe), and complexes of ferric salts with nitrilotriacetic acid (Fe-NTA) on DNA damage, the protective effects of zinc-MT (Zn-MT) on DNA damage of Fe salts or Fe-NTA were investigated in vitro.