[A therapeutic comparison between hemodilution and pentoxifylline in arterial obstructive disease. An objective assessment by quantitative Doppler sonography].

The effects of a five-week course of haemodilution or pentoxifylline were compared in two matched groups of 10 patients each (18 men, 2 women; mean age 63 [47-77] years) with peripheral vascular disease of the legs, using clinical findings and Doppler ultrasound measurements as the criteria. Ten patients (group I) had six venesections of 400 ml each followed by the injection of 500 ml low-molecular dextran (10%), while the other ten (group II) received 400 mg pentoxifylline four times daily by mouth after initial intravenous loading. Pain-free and maximal walking distance increased in group I by 139 and 598 m, respectively (P less than 0.

[Latest state of pharmacotherapy in the pulmonary heart disease (author's transl)].

With the exception of the decompensated state there is no special therapy in the pulmonary heart disease. Therapy is mainly directed to the original lung disease. Regarding the frequency of the ventilative-hypoxic type of the cor pulmonale chronicum the main thing of this lecture is the improvement of oxygen supply and thereby the lowering of pulmonary artery pressure pathologically raised by drug-induced bronchial dilatation.

[Recent aspects of pharmacotherapy in obstructive airway diseases with special regard to bronchial asthma (author's transl)].

After demonstration of the pathophysiologic principles bronchial obstruction a review of the pharmacotherapeutic possibilities is presented. The main of therapeutics comprehends beta-2-receptor stimulants in combination with theophylline derivatives. Further therapeutic efforts with anticholinergic drugs (ipratropium bromide) preponderant in chronic bronchitis or intrinsic bronchial asthma respectively and with cromolyn sodium in extrinsic asthma are valuable.

[Role of life style and nutrition in the etiology, prevention and therapy of coronary disease with special reference to lipid metabolism].

Issuing from the epidemiological situation of the angiocardiopathies the importance of the factors of risk for the coronary heart disease are emphasized with special consideration of the disturbances of lipometabolism. Essential constituent in the reduction of the factors of risk, particularly obesity, hyperlipoproteinaemia and hypertension, is the change of the habits of nutrition. An increased supply of manifold unsaturated fatty acids, an adequate to the disturbances of lipometabolism type-specific restriction of the cholesterol and carbohydrate intake and a reduction of the saline supply are to be recommended.