The Himalayan rabbit (Oryctolagus cuniculus L.): spontaneous incidences of endpoints from prenatal developmental toxicity studies.

The historical database represents the spontaneous, i.e. normal changes of characters, in laboratory animals, and is a must for the assessment of toxic effects of compounds.

Comparative cardiac toxicity of the i.v. administered benzimidazole pyridazinon derivative Pimobendan and its enantiomers in female Beagle dogs.

The new positive-inotropic and vasodilatating drug Pimobendan (racemate), 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazole-5-yl]-5-methyl-3 (2-H)-pyridazinone, and its enantiomers were investigated with regard to their cardiotoxicity in young adult female Chbb: Beagle dogs. The racemate and the (-)-isomer (eutomer) were intravenously injected once daily for 4 consecutive weeks at doses of 0.25, 0.

[Diagnosis and therapy of acquired heart valve defects in patients of advanced age].

Advantages and disadvantages of elective cardiothoracic surgery in patients over the age of 60 with acquired heart valve defects are shown in table 8. An important improvement in survival rates can be noticed in patients with decompensated aortic and mitral valve defects. Quality of life is ameliorated in all patients who need an operation because of valvular heart defect, mainly in aortic stenosis, which on principle can be considered as operable.