Protein kinases are a protein family that plays an important role in several complex diseases such as cancer and cardiovascular and immunological diseases. Protein kinases have conserved ATP binding sites, which when targeted can lead to similar activities of inhibitors against different kinases. This can be exploited to create multitarget drugs.
View Article and Find Full Text PDFThis paper proposes a methodology for sentiment analysis with emphasis on the emotional aspects of people visiting the Herculaneum Archaeological Park in Italy during the period of the COVID-19 pandemic. The methodology provides a valuable means of continuous feedback on perceived risk of the site. A semantic analysis on Twitter text messages provided input to the risk management team with which they could respond immediately mitigating any apparent risk and reducing the perceived risk.
View Article and Find Full Text PDFInt J Risk Saf Med
August 2022
Background: The pandemic that began around February 2020, caused by the viral pathogen SARS-CoV-2 (COVID-19), has still not completed its course at present in June 2022.
Objective: The open research to date highlights just how varied and complex the outcome of the contagion can be.
Method: The clinical pictures observed following the contagion present variabilities that cannot be explained completely by the patient's age (which, with the new variants, is rapidly changing, increasingly affecting younger patients) nor by symptoms and concomitant pathologies (which are no longer proving to be decisive in recent cases) in relation to medium-to-long term sequelae.