Publications by authors named "G Tosto"
Article Synopsis
- Blood-based biomarkers like p-tau217 are being studied for their effectiveness in diagnosing Alzheimer's disease (AD), but previous research has mainly focused on non-Hispanic White populations, leading to a knowledge gap across different ethnic backgrounds.
- A new study involving Peruvians, including mestizos and indigenous groups, examined plasma p-tau217 in 525 individuals, revealing significant associations between the biomarker and AD, especially in those with the APOE-e4 allele, although it did not distinguish between healthy controls and mild cognitive impairment (MCI).
- The results indicated that p-tau217 levels correlated well with cognitive performance and had an impressive classification performance (ROC-AUC of 82.82%), marking a significant contribution to understanding AD in diverse
Mexican Health and Aging Study Biomarker and Genetic Data Profile.
J Gerontol A Biol Sci Med Sci
December 2024
The Mexican Health and Aging Study (MHAS) is one of the largest ongoing longitudinal studies of aging in Latin America, with six waves over 20 years. MHAS includes sociodemographic, economic, and health data from a nationally representative sample of adults 50 years and older in urban and rural Mexico. MHAS is designed to study the impact of diseases on adults' health, function, and mortality.
View Article and Find Full Text PDFCOVID-19 and coworker conflict among emergency medical service clinicians.
J Am Coll Emerg Physicians Open
October 2024
Objectives: Safety policies enacted in response to the emergence of coronavirus disease 2019 (COVID-19) have greatly affected the working environments of emergency medical service (EMS) clinicians. Our objective was to evaluate whether changes in the EMS environment during the COVID-19 pandemic were associated with increased workplace conflict.
Methods: This evaluation was a cross-sectional analysis of a random sample of 19,497 national certified EMS clinicians who were selected to receive an electronic survey in April 2022.
Article Synopsis
- Genetic variants in the ABCA7 gene are linked to a higher risk of Alzheimer's disease (AD), but the exact function of ABCA7 in AD development remains uncertain.* -
- Researchers created a zebrafish model lacking the abca7 gene, revealing that ABCA7 is essential for the expression of neuropeptide Y (NPY) and other neurotrophic factors vital for brain health.* -
- Findings suggest that decreased NPY due to impaired ABCA7 function contributes to synaptic issues and a higher risk of AD, with clinical data showing a correlation between NPY levels and disease progression.*
Article Synopsis
- Genetic and epigenetic factors contribute to Alzheimer's disease risk, particularly focusing on CpG-related single nucleotide polymorphisms (CGS) in diverse populations like Caribbean Hispanics and Non-Hispanic Whites.
- A genome-wide association study identified six genetic loci significant for Alzheimer's in Caribbean Hispanics, with some loci also showing importance in Non-Hispanic Whites.
- The research revealed that DNA methylation at these loci impacts mRNA expression and is associated with brain activity in relation to Alzheimer’s progression, highlighting potential pathways involved in neuronal function.