Publications by authors named "G Tonti"

We sought to assess cardiac magnetic resonance derived left ventricular hemodynamic forces (HDF) in athletes compared to patients with hypertension. Sixty athletes and 48 hypertensive patients were studied. HDF were measured during the entire cardiac cycle, the systolic phase, suction, early LV filling, and atrial thrust.

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Aims: Cardiac resynchronization therapy (CRT) may induce left ventricular (LV) reverse remodelling (=LV response) in patients with heart failure. Intraventricular pressure gradients can be quantified using echocardiography-derived haemodynamic forces (HDF). The aim was to evaluate the association between baseline HDF and LV response and to compare the change of HDF after CRT between LV responders and LV non-responders.

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Echocardiography-derived hemodynamic forces (HDF) allow calculation of intraventricular pressure gradients from routine transthoracic echocardiographic images. The evolution of HDF after cardiac resynchronization therapy (CRT) has not been investigated in large cohorts. The aim was to assess HDF in patients with heart failure implanted with CRT versus healthy controls.

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Article Synopsis
  • - A new tool using echo-derived haemodynamic forces (HDFs) was tested to predict treatment response to sacubitril/valsartan in heart failure patients with reduced ejection fraction (HFrEF), indicating its potential for evaluating heart performance.
  • - In a study of 89 HFrEF patients, those who responded to treatment had significantly higher whole cardiac cycle LV strength (wLVS), making it a key predictor of positive treatment outcomes and future cardiovascular events.
  • - An increase in wLVS over six months was found to be a strong indicator of improved prognosis, with significant statistical support showing that patients with higher wLVS had lower risks of heart-related hospitalizations and deaths.
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