Publications by authors named "G Tonon"
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.
View Article and Find Full Text PDFIt is unclear how cells counteract the potentially harmful effects of uncoordinated DNA replication in the context of oncogenic stress. Here, we identify the WRAD (WDR5/RBBP5/ASH2L/DPY30) core as a modulator of DNA replication in pancreatic ductal adenocarcinoma (PDAC) models. Molecular analyses demonstrated that the WRAD core interacts with the replisome complex, with disruption of DPY30 resulting in DNA re-replication, DNA damage, and chromosomal instability (CIN) without affecting cancer cell proliferation.
View Article and Find Full Text PDFIn recent years, the demand for solid, thin, and flexible energy storage devices has surged in modern consumer electronics, which require autonomy and long duration. In this context, hybrid supercapacitors have become strategic, and significant efforts are being made to develop cells with higher energy densities while preserving the power density of conventional supercapacitors. Motivated by these requirements, we report the development of a new high-performance dual-redox-mediator supercapacitor.
View Article and Find Full Text PDFUntargeted metabolomics UHPLC-HRMS workflows typically employ narrowbore 2.1-mm inner diameter (i.d.
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