CITRULLINATED AND MALONDIALDEHYDE-ACETALDEHYDE MODIFIED FIBRINOGEN ACTIVATES MACROPHAGES AND PROMOTES PROFIBROTIC RESPONSES IN HUMAN LUNG FIBROBLASTS.

The objective of this study was to assess fibrinogen (FIB) co-modified with citrulline (CIT) and/or malondialdehyde-acetaldehyde (MAA) initiates macrophage-fibroblast interactions leading to extracellular matrix (ECM) deposition that characterizes rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Macrophages (Mϕ) were stimulated with native-FIB, FIB-CIT, FIB-MAA or FIB-MAA-CIT. Supernatants (SN) (Mϕ-SN [U-937-derived] or MϕP-SN [PBMC-derived]) or direct antigens were co-incubated with human lung fibroblasts (HLFs).

"Someone is there with you through this [pregnancy] that isn't seeing you through a negative lens": Considerations for integrating doula referrals into opioid treatment programs.

Introduction: Pregnancy-associated mortality involving opioids represents a significant public health issue. Limited social support is a known factor, contributing to a more complex recovery and a greater risk for relapse and overdose. Community-based doulas have been used in other marginalized populations yet are under-studied among pregnant and parenting persons with Opioid Use Disorder (OUD).

MUC5B Promoter Variant and Survival in Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Objective: Investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD).

Methods: We studied participants in the Veteran Affairs Rheumatoid Arthritis (VARA) registry with validated ILD diagnoses. Participants were followed until death or end of study period.

A polychloride-enabled synthesis of [NEtMe][PCl] serving as a potential PCl-storage and PCl-reagent.

Reaction of the ionic liquid [NEtMe][Cl] with white phosphorus (P) gives, quantitatively, hexachlorophosphate [NEtMe][PCl]. This compound shows similar reactivity as PCl, as confirmed for the reaction with phenol, carboxylic acids and ammonium chloride. At elevated temperature, [NEtMe][PCl] releases PCl and can therefore be used as a potential PCl-storage material.