Restoring cefepime activity against multidrug-resistant KPC-producing by combination with boronic acid inhibitors, MB076 and S02030.

Foremost in the design of new β-lactamase inhibitors (BLIs) are the boronic acid transition state inhibitors (BATSIs). Two highly potent BATSIs being developed are S02030 and MB076 strategically designed to be active against cephalosporinases and carbapenemases, especially KPC. When combined with cefepime, S02030 and MB076 demonstrated potent antimicrobial activity against laboratory and clinical strains of expressing a variety of class A and class C β-lactamases, including and .

Amide Derivative of Arjunolic Acid TA-1,4-BiP Enhances ROSmediated Apoptosis in Colorectal Cancer Cells.

Introduction: Arjunolic acid, a well-known natural product with various medicinal properties, was isolated from the heartwood of Terminalia arjuna. Various amides of arjunolic acid were synthesized using different aryl and cyclic amines, characterized, and evaluated for their anti-cancer activities at the National Cancer Institute (NCI).

Method: All the derivatives were active against all the cell lines of NCI compared to the parent molecule arjunolic acid.

Thick skin and thicker arteries: case report on a rare cause of hypertension.

Renovascular hypertension is the second leading cause of hypertension. Twenty-seven genes have been attributed to monogenic renovascular hypertension at present. We present a 15-year-old boy with facial dysmorphism, thick skin and renovascular hypertension with a novel gain-of-function variant in SMAD4 gene suggesting Myhre syndrome.

Stress Distributions and Luminescent Responses of Mechanoluminescent Cylinders with Various Sizes and Loading Paths.

Mechanoluminescent (ML) materials emit light by trapping and releasing charge carriers under mechanical stress. However, previous studies do not fully reveal the relationship between emitting light intensity and mechanical stress, thereby affecting the accuracy of stress measurement. This study addresses this gap by systematically investigating ML cylinders with various sizes and loading paths using theoretical analysis and simulations, focusing on the maximum contact stress, equivalent stress distribution, and the relationship between the strain energy density and light intensity at the point of maximum contact stress.

Nutritional Counseling During Chemotherapy Treatment: A Systematic Review of Feasibility, Safety, and Efficacy.

Dietary interventions during chemotherapy hold promise for clinical and supportive care outcomes. We systematically investigated the feasibility, safety, and efficacy of nutritional counseling conducted during chemotherapy. Studies prospectively implemented nutrition counseling during chemotherapy.