Four cases of natalizumab-related PML: a less severe course in extended interval dosing?

Background: Progressive multifocal leukoencephalopathy (PML) is a severe adverse event of natalizumab (NTZ). The administration of NTZ with extended interval dosing (EID) has been proposed as a strategy to potentially reduce the incidence of PML while maintaining its therapeutic efficacy.

Methods: In the current paper, we describe 4 cases of NTZ-PML in EID included in the Italian PML cohort.

Mutational analysis of EFHC1 gene in Italian families with juvenile myoclonic epilepsy.

Objectives: Mutations in the EFHC1 gene have been reported in six juvenile myoclonic epilepsy (JME) families from Mexico and Belize. In this study, we screened 27 unrelated JME Italian families for mutations in the EFHC1 gene.

Materials And Methods: Twenty-seven families (86 affected individuals, 52 women) with at least two affected members with JME were selected.

Incidence of primary intracranial tumors in the province of Bolzano 1980-84.

182 new cases of primary intracranial neoplasia were diagnosed in the province of Bolzano in the five years 1980-84, yielding a crude incidence of 8.4 cases per 100.000 inhabitants per year.