Publications by authors named "G T Todaro"
Fatty liver disease has been identified as a marker of malnutrition in different clinical settings. Recently, the COntrolling NUTritional status score (CONUT score) emerged as a promising tool for malnutrition assessment. Our aim was to evaluate short-term outcomes among patients with malnutrition-related liver steatosis in an Internal Medicine department.
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- The EVI1 gene is linked to a particularly aggressive form of acute myeloid leukemia (AML) characterized by abnormalities on chromosome 3q26.
- Selective and pan-histone deacetylase inhibitors (HDACis) have been identified as effective treatments for this type of leukemia by repressing EVI1 expression.
- The study suggests that the PA2G4 protein plays a key role in EVI1-related leukemia, and targeting PA2G4 could enhance the effects of HDACis, highlighting the potential for combination therapies in patients with 3q26 AML.
DNA damage resistance is a major barrier to effective DNA-damaging therapy in multiple myeloma (MM). To discover mechanisms through which MM cells overcome DNA damage, we investigate how MM cells become resistant to antisense oligonucleotide (ASO) therapy targeting Interleukin enhancer binding factor 2 (ILF2), a DNA damage regulator that is overexpressed in 70% of MM patients whose disease has progressed after standard therapies have failed. Here, we show that MM cells undergo adaptive metabolic rewiring to restore energy balance and promote survival in response to DNA damage activation.
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- PEST domain mutations are commonly found in various hematopoietic malignancies, like T-ALL and CLL, and they contribute to tumor development by enhancing Notch signaling, which leads to increased cell growth and survival.* -
- Currently, there is no specific treatment for cancers linked to PEST domain mutations, but several Notch inhibitors, including CAD204520, are under investigation, showing promise in combating T-ALL and increasing sensitivity in CLL and MCL cases with these mutations.* -
- The study demonstrates that CAD204520, especially when combined with existing treatments like venetoclax and ibrutinib, enhances therapeutic efficacy in cancers with PEST mutations, highlighting its potential as a novel treatment strategy for