Publications by authors named "G T Sica"
Environmental pollution poses a significant risk to public health, as demonstrated by the bioaccumulation of aluminum (Al) in colorectal cancer (CRC). This study aimed to investigate the potential mutagenic effect of Al bioaccumulation in CRC samples, linking it to the alteration of key mediators of cancer progression, including immune response biomarkers. Aluminum levels in 20 CRC biopsy samples were analyzed using inductively coupled plasma mass spectrometry (ICP-MS).
View Article and Find Full Text PDFBackground: Prostate cancer is the most common diagnosed tumor and the fifth cancer related death among men in Europe. Although several genetic alterations such as ERG-TMPRSS2 fusion, MYC amplification, PTEN deletion and mutations in p53 and BRCA2 genes play a key role in the pathogenesis of prostate cancer, specific gene alteration signature that could distinguish indolent from aggressive prostate cancer or may aid in patient stratification for prognosis and/or clinical management of patients with prostate cancer is still missing. Therefore, here, by a multi-omics approach we describe a prostate cancer carrying the fusion of TMPRSS2 with ERG gene and deletion of 16q chromosome arm.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to provide updated evidence for managing stage I colon cancer (CC) post-surgery, focusing on recurrence rates and risk factors.
- Despite low recurrence risk, some guidelines suggest intensive follow-up is unnecessary, but data on actual recurrence rates is limited.
- The findings reveal a 5% recurrence rate, primarily systemic, with significant risk factors including tumor characteristics and patient demographics, suggesting a need for improved postoperative follow-up strategies.
Article Synopsis
- * Recent literature has focused on new technologies to improve the diagnosis and prognosis of head and neck squamous cell carcinoma (HNSCC), with particular attention on dual-energy computed tomography (DECT).
- * DECT uses two X-ray energy levels to create detailed images that help differentiate materials, improve contrast, and assist in tumor assessment, potentially offering significant advantages in managing HNSCC.
Article Synopsis
- Lung cancer is a leading cause of cancer deaths worldwide, and this research investigates pCASTOR1 as a potential prognostic marker, focusing on its role in lung adenocarcinoma (LUAD) patients with KRAS mutations.* -
- The study found that tumor cells have higher pCASTOR1 scores than non-tumor cells, with elevated scores linked to significantly worse overall survival and relapse-free survival, particularly in male patients with KRAS mutations.* -
- Elevated pCASTOR1 scores could be useful as biomarkers to predict treatment outcomes, suggesting that monitoring these scores may help optimize therapies for male LUAD patients with KRAS mutations.*