The ZmAHL25-ZmPUB19-ZmMPK5 Module Positively Regulates Resistance to Rhizoctonia solani in Maize.

Ubiquitin-mediated proteolysis is a crucial mechanism in plant defenses against pathogens. However, the role of E3 ubiquitin ligases in the maize (Zea mays) defense response against Rhizoctonia solani, a major soil-borne fungal pathogen that causes banded leaf and sheath blight, remains unclear. We previously identified the maize ZmPUB19 gene, which encodes a U-box E3 ubiquitin ligase and is upregulated upon R.

Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI.

Background: Beta thalassemia major (β-TM) is a severe genetic anemia with considerable phenotypic heterogeneity. This study investigated whether genotype correlates with distinct myocardial iron overload patterns, assessed by cardiovascular magnetic resonance (CMR) T2* values.

Methods: CMR data for cardiac iron deposition evaluation, which recruited pediatric participants between January 2021 and December 2024, were analyzed with CVI42.

Effect of myoglobin on the flavor, color and texture of high-moisture soy protein concentrate -wheat gluten extrudates.

The rising demand for plant-based meat analogues presents challenges in replicating the sensory qualities of animal meat. This study investigates the impact of Pichia-derived porcine myoglobin (PMb) and bovine hemoglobin (BHb) on the flavor profile, sensory attributes, macrostructure, color, and texture of high-moisture extruded soy protein concentrate-wheat gluten. The addition of PMb and BHb significantly altered the flavor profile by decreasing aldehyde content (hexanal and nonanal), while the contents of ketones (2,3-octanedione and 3,5-octadien-2-one), pyrazines (2-ethyl-6-methylpyrazine), and furans (2-pentylfuran) were increased.

A Zn-doped SbTe flexible thin film with decoupled Seebeck coefficient and electrical conductivity band engineering.

SbTe-based flexible thin films can be utilized in the fabrication of self-powered wearable devices due to their huge potential in thermoelectric performance. Although doping can significantly enhance the power factor value, the process of identifying suitable dopants is typically accompanied by numerous repeating experiments. Herein, we introduce Zn doping into thermally diffused p-type SbTe flexible thin films with a candidate dopant validated using the first-principles calculations.

Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment.

Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment of specific microbial communities within tumors of gastric cancer patients, possibly affecting the tumor microenvironment by immune modulation, metabolic processes, and inflammatory responses. Based on the results of in vivo experiments and intratumoral microbiota analysis, we found that Streptococcus mitis can inhibit gastric cancer progression via suppressing M2 macrophage polarization and infiltration, as well as altering the intratumoral microbial community.