The long way from raw data to NAM-based information: Overview on data layers and processing steps.

Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits. The data processing pipeline provided in the test method description is often highly complex. Usually, multiple layers of data, ranging from a machine-generated output to the final hit definition, are considered.

Enhancing Driving Safety through User Experience Evaluation of the C-ITS Mobile Application: A Case Study of the DARS Traffic Plus App in a Driving Simulator Environment.

The paper evaluates the DARS Traffic Plus mobile application within a realistic driving simulator environment to assess its impact on driving safety and user experience, particularly focusing on the Cooperative Intelligent Transport Systems (C-ITS). The study is positioned within the broader context of integrating mobile technology in vehicular environments to enhance road safety by informing drivers about potential hazards in real time. A combination of experimental methods was employed, including a standardised user experience questionnaire (meCUE 2.

Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting.

Background: Chronic infection by Loa loa remains an unsolved immunological paradox. Despite harboring subcutaneously migrating adult worms and often high densities of microfilariae, most patients experience only relatively mild symptoms, yet microfilaricidal treatment can trigger life-threatening inflammation. Here, we investigated innate cell populations hypothesized to play a role in these two faces of the disease, in an endemic population in Gabon.

Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections.

Background: The parasitic disease loiasis is associated with significant morbidity and mortality. Individuals with hyper-microfilaremia (greater than 20,000 microfilariae per mL of blood) may suffer from serious treatment-related or spontaneous adverse events. Diagnosing loiasis remains complex and primarily relies on direct parasite detection.