Publications by authors named "G Sunder-Plassmann"
Introduction: Complement 3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) have high risks for disease recurrence and allograft loss in transplant kidneys. Pegcetacoplan (targeted complement 3 [C3]/C3b inhibitor) may prevent excessive deposition of C3 and complement 5 [C5] breakdown products and associated renal damage.
Methods: NOBLE (NCT04572854) is a prospective, phase 2, multicenter, open-label, randomized controlled trial evaluating the efficacy and safety of pegcetacoplan in posttransplant patients with recurrent C3G or IC-MPGN.
Article Synopsis
- Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and a major reason for needing kidney transplants globally.
- The progression of the disease varies greatly among individuals due to genetic and environmental factors, with specific tools like the PROPKD score and Mayo Imaging Classification (MIC) used to assess risk of kidney failure.
- A study showed that these two assessment methods do not align well in categorizing risk levels, suggesting that while MIC is useful for risk assessment, it should be combined with additional genetic and phenotypic details for improved accuracy.
Introduction: The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is alleged to enable a proinflammatory state that leads to the activation of the coagulation and the complement cascade. In this study, we aimed to establish the impact of the COVID-19 pandemic on patients with new onset of cTMA/aHUS in the Vienna TMA cohort and whether COVID-19 or SARS-CoV-2 vaccinations would pose a greater risk of initial manifestation of cTMA/aHUS.
View Article and Find Full Text PDF: The diagnosis and follow-up of cardiac involvement in Fabry disease constitutes an important challenge for clinicians caring for affected patients. Combining cardiac imaging with laboratory biomarkers appears most appropriate for longitudinal monitoring. Therefore, we examined the use of NT-proBNP and its association with imaging findings in patients with Fabry disease.
View Article and Find Full Text PDFArticle Synopsis
- Fabry disease (FD) is a rare genetic disorder that affects multiple organs, particularly the heart, kidneys, and brain, and researchers are exploring neurofilament light chains (sNfL) as a potential biomarker for nerve damage in these patients.
- A study measured serum NfL levels in 50 FD patients compared to 30 healthy individuals, finding significantly higher sNfL levels in FD patients, especially in males and those with brain white matter lesions.
- The elevated sNfL levels correlated with clinical disease severity and renal function, suggesting that sNfL could be a valuable indicator of neuroaxonal injury and may reflect broader cerebrovascular damage in FD patients.