Evaluating the effect of immune checkpoint inhibitor treatment on chronic obstructive pulmonary disease in lung cancer patients.

Immune checkpoint inhibitors (ICIs) are first line treatment for advanced lung cancer. Tobacco use is a shared risk factor for lung cancer and chronic obstructive pulmonary disease (COPD). Although many patients with COPD and lung cancer receive ICIs, the impact of ICIs on COPD is unknown.

Crystallite Size Effects on the Heat of Water Intrusion/Extrusion into/from Metal-Organic Frameworks.

The wettability of nanoporous materials is a key property for a diverse range of applications. However, the heat generated in this process remains largely unexplored. Herein, the heats of intrusion/extrusion into/from ZIF-8 + water systems of various ZIF-8 crystallite sizes were measured at different temperatures.

Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial.

Background: In the ESCAPE-NA1 trial, treatment with nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, was associated with improved functional outcome among patients with acute ischaemic stroke due to large vessel occlusion undergoing endovascular thrombectomy without co-treatment with an intravenous thrombolytic agent. There was no benefit when intravenous thrombolytic agent co-treatment was used. We sought to confirm the clinical benefit of nerinetide in the absence of previous intravenous thrombolytic drug treatment.

Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications.

Introduction: New bioactive hybrid materials to prevent biofilm-induced biodeterioration are a significant challenge in indoor environments, where contaminants from microbial films compromise structural integrity and contribute to air pollution, posing health risks from prolonged exposure to biological agents.

Methods: For the first time, diatomaceous earth or diatomite (Dt) was functionalized with quaternary ammonium salt (QAS) and a biogenic compound, citronellol, to develop a bioactive hybrid material (Dt*QC). The hybrids obtained were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR).

Effects of Breathing Exercises on Neck Pain Management: A Systematic Review with Meta-Analysis.

Given the relationship between reduced pulmonary and respiratory muscle function in neck pain, incorporating breathing exercises into neck pain management may be beneficial. : The purpose of this study was to investigate the benefits of breathing exercises for treating neck pain. : We searched PubMed (MEDLINE), PEDro, CINAHL, Scopus, and EMBASE databases, up to the 28 of February 2024.