Publications by authors named "G St Krasopoulos"
Aortitis, defined as inflammation of the aorta, can lead to aneurysms and dissections. Intra-operative sampling is essential for diagnosis, with many cases presenting asymptomatically as clinically isolated aortitis. Previous studies investigating aortitis in major aortic surgery have been limited by low intra-operative sampling.
View Article and Find Full Text PDFObjectives: Thoracic aortic aneurysms and dissections provide a complex surgical cohort termed thoracic aortic surgery. Regular follow-up at specialist clinics with cross-sectional imaging is recommended. Identifying risk factors that lead to re-operations as well as the requirement for and appropriate length of follow-up remain points of debate.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the external validity of the Barts Surgical Infection Risk (B-SIR) tool for predicting surgical site infections (SSI) in cardiac surgery patients compared to other risk tools, ACRI and BHIS.
- An analysis of 6,022 patients showed that B-SIR had a better predictive accuracy (AUC=0.686) for SSI than both ACRI (AUC=0.614) and BHIS (AUC=0.610).
- The findings suggest that B-SIR could be a valuable tool for routine use in clinical practice to improve risk assessment for infections after cardiac surgeries.
Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000 deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the cardiac muscle, which results in myocardial infarction (MI). Junctophilin-2 (JPH2) is a membrane protein that ensures efficient calcium handling and proper excitation-contraction coupling.
View Article and Find Full Text PDFObjectives: The premise of this retrospective study was to evaluate the intraoperative use of closed-incision negative pressure therapy (ciNPT) to help reduce the incidence of postoperative sternal wound infections in multimorbid patients with an elevated risk of developing a sternal wound infection post cardiac surgery versus a cohort that received standard-of-care dressings.
Methods: Data for all adult patients were collected from each cardiothoracic surgery unit across 3 hospitals in the United Kingdom. High-risk patients had 2 or more recognized risk factors.