TARGETING LUNG HEME IRON BY AEROSOL HEMOPEXIN ADMINSTRATION IN SICKLE CELL DISEASE PULMONARY HYPERTENSION.

Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.

Utilization of RT-PCR and Optical Genome Mapping in Acute Promyelocytic Leukemia with Cryptic Rearrangement: A Case Discussion and Systemic Literature Review.

Background: Acute promyelocytic leukemia (APL) is characterized by abnormal promyelocytes and t(15;17)(q24;q21) . Rarely, patients may have cryptic or variant rearrangements. All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) is largely curative provided that the diagnosis is established early.

A new species of eight-gilled hagfish (Myxinidae: Eptatretus) from the deep waters of the Lakshadweep Sea, India.

A new species of eight-gilled hagfish genus Eptatretus (Myxinidae) is described based on five specimens trawled on the upper continental slope off Kollam, Kerala, India, northern Indian Ocean. Eptatretus gopali sp. nov.

Cross-sectional analysis of risk factors associated with the coexistence of three undernutrition indicators among children aged 0-23 months in Tanzania.

Background: Undernutrition in children under two years is a persistent challenge in Tanzania. This study investigates demographic, maternal, and child-related factors associated with stunting, wasting, and underweight coexistence.

Methods: Secondary data from 2,158 children aged 0-23 months in the 2022 Tanzania Demographic and Health Survey (TDHS) were analyzed.

Patients With Shoulder Labral Tears Search the Internet to Understand Their Diagnoses and Treatment Options.

Purpose: To analyze the most frequently searched questions associated with shoulder labral pathology and to evaluate the source-type availability and quality.

Methods: Common shoulder labral pathology-related search terms were entered into Google, and the suggested frequently asked questions were compiled and categorized. In addition, suggested sources were recorded, categorized, and scored for quality of information using JAMA benchmark criteria.