Publications by authors named "G Sobczyk"
In this paper, we outline the research conducted by the first named author and his associates on the axiom-preserving, thus isotopic completion of quantum mechanics into hadronic mechanics according to the historical legacy by A. Einstein, B. Podolsky and N.
View Article and Find Full Text PDFAt present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed to deliver the first concise summary of treatment options in patients with ACC mimicking a thyroid tumor.
View Article and Find Full Text PDFCytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved. Here we show that SILAC-based proteomic methods can be used to characterize the rapid chemoattractant-induced dynamic changes in the actin-myosin cytoskeleton and regulatory elements on a proteome-wide scale with a second to minute timescale resolution. This approach provides novel insights in the ensemble kinetics of key cytoskeletal constituents and association of known and novel identified binding proteins.
View Article and Find Full Text PDFArticle Synopsis
- Rhabdomyosarcoma (RMS) is a solid tumor linked to issues in skeletal muscle development, and while it commonly occurs in areas like the head, neck, and genitourinary tract, its occurrence in the larynx is rare with limited cases documented in adults.
- A specific case of embryonal rhabdomyosarcoma was reported in a 33-year-old man, who underwent hemilaryngectomy after chemotherapy failed, and has remained free of recurrence for 62 months.
- Early diagnosis and surgical options, along with radiotherapy, are essential for treatment, and laryngeal RMS tends to have a better prognosis due to its detectability and surgical accessibility.
Three Rat1/Xrn2 homologues exist in Arabidopsis thaliana: nuclear AtXRN2 and AtXRN3, and cytoplasmic AtXRN4. The latter has a role in degrading 3' products of miRNA-mediated mRNA cleavage, whereas all three proteins act as endogenous post-transcriptional gene silencing suppressors. Here we show that, similar to yeast nuclear Rat1, AtXRN2 has a role in ribosomal RNA processing.
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