[Radioprogestins. Their clinical use].

It was obtained by synthesis a radioprogestin-iodine-131 and proved in two patients with hormono-dependent meningioma to progesterone with very good results in the scan of cerebral tumours localization; and in one patient in the treatment of this kind of tumour. No radiotoxicity or intolerance was present until today in six month of follow-up of this preliminary uses of radioprogestin in cerebral tumours hormono-dependent to progesterone; so it is proposed the use of this new radiopharmaco for the diagnosis and treatment of this tumours.

[Radioactive antiestrogens: their clinical use].

Using antiestrogen labelled with iodine-131 we proved the useful as diagnostic and therapeutic tools to identified hormone dependent cancers in breast with very encorageous results in 7 cases of human cancer. The method was simple and safe and similar methods for scanning of prostate tumors dependent are in current research in our laboratory and will be object of other communications.

Scan of Hypothalamic Satiety Centers in the Control of Obesity: a preliminary report.

Using thioglucose labeled with goid-1 98 (Au-1 98) at doses of 2OµCi per patient, we took specific scans of the hypothalamic satiety centers in 50 normal volunteers and in 50 obesity patients, due to the ability of the hypothalamic satiety centers to take up thioglucose in their glucostat receptors. From the 50 obesity patients, two were classified as having hypothalamic obesity. The rest were controlled with serial scans in combination with nutritional, surgery and clinical control of obesity, with satisfactory results for the 'obesity team'.

Cysticercosis of the nervous system. Treatment by means of specific internal radiation.

Five hundred patients with cysticercosis of the nervous system were evaluated by scanning that used anti-Cysticercus antibodies labeled with indium 113. The same antibodies, labeled with iodine 131, were used for radioimmunotreatment. Ninety-six percent of the patients had good or excellent results, whereas only 4% had poor results.

[Diagnosis and treatment of trichinosis by means of radionuclide].

Using the same technique that gave such good results in cysticercosis and other parasitic diseases we obtained antibodies labelled against trichinosis and proved their diagnostic value by scan in infected rats. These same antibodies at lethal dose, median, (LD50) radiolysed trichina larvae without damage to the animal. Experimental results are very encouraging and their potential use in human subjects are undergoing research in our laboratory and will be the object of a future report.