Pulsatile gonadotropin releasing hormone (GnRH)--treatment for hypothalamic amenorrhoea causing infertility.

Thirty women with hypothalamic amenorrhoea and infertility were treated with pulsatile GnRH s.c. without monitoring with estradiol and ultrasonography.

Pulsatile GnRH therapy--an alternative successful therapy for induction of ovulation in infertile normo- and hyperprolactinaemic amenorrhoeic women with pituitary tumours.

Pulsatile treatment with gonadotrophin-releasing hormone (GnRH) was given to induce ovulation in 3 infertile, amenorrhoeic women with pituitary tumours not suitable for conventional therapy with human gonadotrophins or dopamine agonists. Two of the women had prolactinomas and the third a non-secreting adenoma. The GnRH therapy resulted in ovulations in all the 3 women, in 2 of them despite marked hyperprolactinaemia.

Induction of male puberty by long-term pulsatile subcutaneous LH-RH therapy.

Prolonged low dose LH-RH treatment was given to induce puberty in a 17.8-year-old male with hypogonadotrophic hypogonadism. The patient had developed panhypopituitarism after transcranial surgery of a craniopharyngioma at the age of 16.

Long-term subcutaneous pulsatile low dose LH-RH administration for treatment of infertile men with secondary hypogonadotrophic hypogonadism.

Chronic pulsatile subcutaneous low dose LH-RH treatment was given to three infertile men with longstanding (2-4 years) secondary hypothalamic pituitary failure. Before the therapy they had very low serum concentrations of gonadotrophins and testosterone. They were impotent and could not produce any ejaculate for sperm analysis.

Subcutaneous pulsatile LH-RH therapy of secondary amenorrhoea.

A novel promising approach to the treatment of anovulatory infertility has been investigated during the last few years. Pulsatile long-term subcutaneous administration of low doses of LH-RH given by means of small portable computerized infusion pumps has proved to be practical, safe and effective for induction of follicular maturation and ovulation in women with amenorrhoea due to inadequate pituitary gonadotrophin secretion.