Dynamic [Tc]Tc-mebrofenin SPECT/CT in preoperative planning of liver resection: a prospective study.

Background: At least 20% of the future liver remnant must function properly after liver tumor resection to avoid post-hepatectomy liver failure (PHLF). [Tc]Tc-mebrofenin scintigraphy and SPECT are unique noninvasive, quantitative methods for evaluating liver function via hepatocellular bilirubin clearance.

Aim: To evaluate the value of dynamic [Tc]Tc-mebrofenin SPECT/CT parameters for predicting clinically relevant PHLF according to the ISGLS criteria.

Different PSMA Radiopharmaceuticals: A Comparative Study of [F]F-PSMA-1007, [F]F-JK-PSMA-7, and [Tc]Tc-PSMA-I&S in the Skeletal System.

Background: Numerous PSMA-based tracers are used for diagnostic prostate cancer imaging, but comprehensive comparisons between multiple ligands are lacking. This study aimed to compare physiological skeletal uptake and tracer uptake in commonly recommended PSMA reference regions across three different PSMA ligands in prostate cancer patients.

Methods: A total of 281 prostate cancer patients were included.

Contribution of Protonation to the Dielectric Relaxation Arising from Bacteriopheophytin Reductions in the Photosynthetic Reaction Centers of .

The pH dependence of the free energy level of the flash-induced primary charge pair PI was determined by a combination of the results from the indirect charge recombination of PQ and from the delayed fluorescence of the excited dimer (P*) in the reaction center of the photosynthetic bacterium , where the native ubiquinone at the primary quinone binding site Q was replaced by low-potential anthraquinone (AQ) derivatives. The following observations were made: (1) The free energy state of PI was pH independent below pH 10 (-370 ± 10 meV relative to that of the excited dimer P*) and showed a remarkable decrease (about 20 meV/pH unit) above pH 10. A part of the dielectric relaxation of the PI charge pair that is not insignificant (about 120 meV) should come from protonation-related changes.

Effects of lipids on the rate-limiting steps in the dark-to-light transition of Photosystem II core complex of .

In our earlier works, we have shown that the rate-limiting steps, associated with the dark-to-light transition of Photosystem II (PSII), reflecting the photochemical activity and structural dynamics of the reaction center complex, depend largely on the lipidic environment of the protein matrix. Using chlorophyll- fluorescence transients (ChlF) elicited by single-turnover saturating flashes, it was shown that the half-waiting time (Δ ) between consecutive excitations, at which 50% of the fluorescence increment was reached, was considerably larger in isolated PSII complexes of () than in the native thylakoid membrane (TM). Further, it was shown that the addition of a TM lipid extract shortened Δ of isolated PSII, indicating that at least a fraction of the 'missing' lipid molecules, replaced by detergent molecules, caused the elongation of Δ .

Diagnostic value of [Tc]Tc-PSMA-I&S-SPECT/CT for the primary staging and restaging of prostate cancer.

Background: A large number of studies have proved that prostate-specific membrane antigen-positron emission tomography/computer tomography (PSMA-PET/CT) provides excellent accuracy in primary staging and restaging of prostate cancer. Less data exist with PSMA-single photon emission computed tomography (SPECT)/CT investigations.

Objective: The aim of this study was to evaluate the performance of [Tc]Tc-PSMA-I&S (for imaging and surgery) in prostate cancer.