Publications by authors named "G Sieberova"
Circulating tumor cells (CTCs) play a pivotal role in tumor dissemination and progression, and are considered to be a critical part of the metastatic cascade. The aim of the present research article was to examine breast cancer-specific mutations in primary breast cancer (PBC) using targeted resequencing. A total of 78 patients with PBC were enrolled into this translational study.
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- Annexin A2 (ANXA2) is a protein related to cancer progression and was studied in relation to circulating tumor cells (CTCs) in breast cancer patients.
- The study included 101 patients, detecting CTCs and analyzing ANXA2 expression through various molecular techniques.
- Results showed that patients with epithelial CTCs had higher ANXA2 levels, while those with CTCs exhibiting an epithelial-mesenchymal transition (EMT) showed increased ANXA2 in the tumor stroma; hormone-negative tumors also showed higher ANXA2 expression in tumor cells.
Background: Circulating tumor cells (CTCs) play a crucial role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. Epithelial to mesenchymal transition (EMT) is involved in cancer invasion and metastasis. The aim of this study was to assess correlation between CTCs and expression of EMT transcription factors TWIST1 and SLUG in breast tumor tissue.
View Article and Find Full Text PDFBackground: Dermatofibrosarcoma protuberans (DFSP) is a relatively common soft-tissue tumor. A more aggressive appearing fibrosarcoma may arise in DFSP, changing its biological behavior. CD34 and apolipoprotein-D are highly expressed in DFSP, but their prognostic significance is uncertain.
View Article and Find Full Text PDFBackground And Aim: Rarely sarcomas develop in previous benign lesions, after a long term disease free interval. We report the experience on these rare cases observed at a single Institution.
Patients And Methods: 12 cases curetted and grafted, without radiotherapy developed sarcomas, between 1970 and 2005, 6.