Posttraumatic Hydrocephalus after Decompressive Craniectomy in 126 Patients with Severe Traumatic Brain Injury.

Objective: Severe traumatic brain injuries (TBIs) occur frequently. In some of these patients decompressive craniectomy (DC) must be performed. Posttraumatic hydrocephalus (PTH) can develop after TBI further damaging the brain.

Intraoperative Micro-Doppler in Cerebral Arteriovenous Malformations.

Introduction: Intraoperative micro-Doppler (IOMD), intraoperative digital substraction angiography (DSA), and microscope-integrated indocyanine green angiography are methods that guide neurosurgical resection of arteriovenous malformations (AVMs) in the brain and minimize the trauma of healthy tissue. In this study we emphasize the use of IOMD in AVM surgery, analyzing the advantages and the limitations of this method. Patients and

Methods: A total of 32 patients were diagnosed with an AVM.

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R(3) PAu(SR'), R = Ph, Cy, Et; SR'H = 6-Mercaptopurine and R = Et; SR'H = 6-Thioguanine.

The antitumour activities of four triorganophosphinegold(I) thiolates, R(2)PAu(S'R) [R = Ph, Cy, Et; SR'H = 6-mercaptopurine and R Et; SR'H = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy(3)PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy(3) PAu(6-MP)] and [Et(3)PAu(6-TG)].

Anti-arthritic activity in rats of some phosphinegold(i) thionucleobases and related thiolates.

A number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph(3)P derivatives and species based on thiopurines were the most effective and that with other complexes enhanced activity was accompanied by greater toxicity.