Climate-Driven Escalation of Global PM Health Burden from Wildland Fires.

Wildland fires constitute a major source of ambient fine particulate matter (PM), significantly impacting air quality and public health. As the climate becomes warmer and drier, fire frequency is projected to rise, yet how the associated health impacts of fire-sourced PM (FPM) respond to climate change remains vague. In this study, we modeled the global concentration and associated premature deaths of FPM over the past two decades.

[Ga]Ga‑FAPI PET/CT in the evaluation of Langerhans cell histiocytosis: comparison with [F]FDG PET/CT.

Purpose: We aimed to explore the value of [Ga]Ga‑FAPI PET/CT for the evaluation of Langerhans cell histiocytosis (LCH) in comparison with [F]FDG PET/CT.

Methods: Thirty-two patients pathologically diagnosed with LCH were enrolled in this study. [Ga]Ga‑FAPI and [F]FDG PET/CT were performed within 1 week to identify disease extent and status.

Dynamic culturing of large cell-loaded PCL/gelatin methacryloyl scaffolds for bone critical size defect repair.

Due to the limited ability to self-repair, the regeneration of bone critical-sized defects (CSD) is a significant challenge. Bone tissue engineering scaffolds are considered promising candidates for CSD repair, but low cell infiltration efficiency and a lack of nutrients greatly restrict bone regeneration abilities. Herein, we developed a dynamic culturing of large biomimetic bone scaffolds, PCL/GelMA@cells that combining 3D printed polycaprolactone (PCL) multi-channel cylinder with gelatin methacryloyl (GelMA) encapsulated with bone marrow mesenchymal stem cells (BMSCs) and rat aortic endothelial cells (RAECs).

Analysis of burden and equality of lower extremity peripheral artery disease in people aged 40 and above in the Belt and Road partner countries from 1990 to 2021.

Objectives: To analyze the disease burden and inequalities of lower extremity peripheral artery disorders (LEPAD) among people aged 40 and above in the Belt and Road partner countries from 1990 to 2021.

Methods: Data were retrieved from the Global Burden of Disease 2021 database. The age-standardized prevalence rates, mortality rates, and the annual rate of years lived with disability (YLDs) of LEPAD were analyzed.

N6-methyladenosine modification of host Hsc70 attenuates nucleopolyhedrovirus infection in the lepidopteran model insect Bombyx mori.

N6-methyladenosine (m6A) is the most prevalent internal modification on mRNA and plays critical roles in various biological processes including virus infection. It has been shown that m6A methylation is able to regulate virus proliferation and host innate immunity in mammals and plants, however, this antiviral defense in insects is largely unknown. Here we investigated function of m6A and its associated methyltransferases in nucleopolyhedrovirus (BmNPV) infection in silkworm.