Automatic analysis of the continuous edges of stone tools reveals fundamental handaxe variability.

The edges of stone tools have significant technological and functional implications. The nature of these edges-their sharpness, whether they are concave or convex, and their asymmetry-reflect how they were made and how they could be used. Similarly, blunt portions of a tool's perimeter hint at how they could have been grasped or hafted and in which directions force could be applied.

Peripheral neuronal activation shapes the microbiome and alters gut physiology.

The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system (ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI tract also harbors a diverse microbiome, but interactions between the ENS and the microbiome remain poorly understood. Here, we activate choline acetyltransferase (ChAT)-expressing or tyrosine hydroxylase (TH)-expressing gut-associated neurons in mice to determine effects on intestinal microbial communities and their metabolites as well as on host physiology.

Signal enhancement for two-dimensional cryo-EM data processing.

Different tasks in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM) require enhancing the quality of the highly noisy raw images. To this end, we develop an efficient algorithm for signal enhancement of cryo-EM images. The enhanced images can be used for a variety of downstream tasks, such as two-dimensional classification, removing uninformative images, constructing ab initio models, generating templates for particle picking, providing a quick assessment of the data set, dimensionality reduction, and symmetry detection.

True, justified, belief? Partisanship weakens the positive effect of news media literacy on fake news detection.

To investigate how people assess whether politically consistent news is real or fake, two studies ( 1,008; 1,397) with adult American participants conducted in 2020 and 2022 utilized a within-subjects experimental design to investigate perceptions of news accuracy. When a mock Facebook post with either fake (Study 1) or real (Study 2) news content was attributed to an alternative (vs. a mainstream) news outlet, it was, on average, perceived to be less accurate.

The limestone spheroids of 'Ubeidiya: intentional imposition of symmetric geometry by early hominins?

Spheroids are one of the least understood lithic items yet are one of the most enduring, spanning from the Oldowan to the Middle Palaeolithic. Why and how they were made remains highly debated. We seek to address whether spheroids represent unintentional by-products of percussive tasks or if they were intentionally knapped tools with specific manufacturing goals.