Publications by authors named "G Severi Boyle"
The lack of patient and public involvement in oropharyngeal dysphagia (OD) intervention studies in Parkinson's disease (PD) can bias the choice of outcomes to be measured in these studies. This study aimed to obtain perspectives of individuals living with OD in PD and family members/caregivers on OD intervention outcomes that are important to them. This is part of a larger Core Outcome Set project.
View Article and Find Full Text PDFEpoxytiglianes are a novel class of diterpene esters. The prototype epoxytigliane, EBC-46 (tigilanol tiglate), is a potent anti-cancer agent in clinical development for local treatment of a range of human and animal tumors. EBC-46 also consistently promotes wound re-epithelialization at the treatment sites, mediated via activation of classical protein kinase C (PKC) isoforms.
View Article and Find Full Text PDFArticle Synopsis
- - The Cytochrome P450 family of enzymes metabolizes around 80% of small molecule drugs, but genetic variants can significantly affect how these drugs are processed, leading to risks of incorrect dosing and severe side effects.
- - Using a technique called VAMP-seq, researchers measured the protein abundance of over 7,600 single amino acid variants in CYP2C19, revealing key structural features essential for enzyme function and showcasing how variants at specific positions can impact protein levels.
- - The study also compared variants in CYP2C19 and CYP2C9, showing that while most amino acid exchanges had little effect, certain changes in substrate recognition sites diminished abundance in CYP2C19, indicating evolutionary trade-offs between stability and