Publications by authors named "G Senthil Murugan"
Article Synopsis
- Type 2 Diabetes Mellitus (T2DM) is a global health concern linked to high blood sugar levels and is influenced by gut microbiome metabolites, particularly imidazole propionate (Imp), which disrupt insulin signaling.
- A proposed therapeutic vaccine targets the enzyme urocanate reductase (UrdA) in gut microbes that produce Imp, using immunoinformatics to identify safe and effective B and T cell epitopes, alongside adjuvants for improved immune response.
- The research includes structural modeling, molecular docking studies to analyze vaccine interaction with immune receptors, and in silico cloning to ensure optimal expression of the vaccine, aiming to provide a new treatment option for T2DM.
A congenital defect in the diaphragm, known as a Bochdalek hernia (BH), is a condition that allows herniation of the abdominal viscera into the thorax. BH is the most common type of congenital diaphragmatic hernia (CDH) and is typically detected on the left side. An ectopic kidney is a rare condition.
View Article and Find Full Text PDFAnion-binding-induced selective aggregation and self-degradation: Influence of positional isomerism on the anion selectivity and mode of binding of an imine-based receptor.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Imine based positional isomers (8E)-N-(4-((E)-(perfluorophenylimino)methyl)benzylidene)-2,3,4,5,6-pentafluorobenzenamine, L and (10E)-N-(3-(E-Perfluorophenylimino)methyl)benzylidene)-2,3,4,5,6-pentafluorobenzenamine, L have been designed, and synthesized by functionalizing two electron deficient aromatic moieties at the para-para'/ortho-ortho' positions in the phenyl core of the L and L respectively. The responses of L and L towards various anionic species are examined. The positional isomers L and L differs not only by showing distinguishable color change upon addition of anions but also differentiates themselves by the way of self-assembling together upon binding with cyanide anion.
View Article and Find Full Text PDFArticle Synopsis
- Graphene is a carbon-based material known for its beneficial properties, and recent developments include a novel cove-edged graphene nanoribbon created using a bottom-up liquid-phase method.
- This nanoribbon features asymmetrical edges formed by hexagonal patterns, combining characteristics of both armchair and zigzag edges, providing exceptional mechanical and electrical properties.
- The article introduces topological indices, which are mathematical values derived from molecular structures, to accurately describe the cove-edged graphene nanoribbons, potentially streamlining laboratory research on their properties.