Comparison of Subureteral Endoscopic Injection of Dextranomer/Hyaluronic Acid and Lich-Gregoir Ureteral Reimplantation in the Treatment of Pediatric Primary Vesicoureteral Reflux: A Prospective Randomized Study.

The gold standard of surgical intervention of vesicoureteral reflux (VUR) is open ureteral reimplantation with high success and low complication rates. However, in recent years, endoscopic injection, dextranomer/hyaluronic acid (Dx/HA), has become an effective therapy for VUR. It is noted that limited prospective randomized trials compare the different surgical techniques of especially endoscopic injection versus open procedures.

Effects of verapamil, prostaglandin F2 alpha, phenylephrine, and noradrenaline on upper urinary tract dynamics.

Objectives: The effects of verapamil (VRP), prostaglandin F2 alpha (PGF2 alpha), phenylephrine, and noradrenaline on upper urinary tract dynamics were studied in vivo, using a pig model involving 12 miniswine which were subjected to acute pharmacologic perfusion studies of the upper urinary tract.

Method: Changes in renal pelvic pressure (Ppvs) and ureteral peristalsis frequency were recorded at 2 mL/min perfusion rate premedication, and then during perfusion with different concentrations of each drug tested in three experiments.

Results: Ppvs showed no significant variations with VRP perfusion when compared with premedication readings, whereas ureteral peristalsis frequency was decreased significantly by 10(-3) mol/L of VRP.

Long-term effects of ureteric stent after ureteric dilation.

Balloon dilation of the right ureterovesical junction (UVJ) and distal ureter to three times its normal caliber was performed in 12 pigs. A right double-J (D-J) stent was inserted after dilation in 6 pigs. Bilateral upper tract dynamics with different perfusion rates (0.

Healing and muscular restoration of the ureteral wall following balloon-induced rupture: an experimental animal model with light microscopic and ultrastructural observations.

Ureteral regrowth following balloon-induced rupture was studied using an animal model, with emphasis on the pattern and cellular events of self-reconstitution in the late phase of healing. At 4 weeks, the ureteral healing/remodeled region included a wedge-shaped muscular component which pointed toward a fibrous central zone, was continuous with the adjacent muscularis propria, and abutted on a thin-lining epithelium. Progressive enlargement, aggregation, and bundle formation of myogenic cells was observed along the centrifugal axis.

Effect of balloon dilation of ureter on upper tract dynamics and ureteral wall morphology.

Sixteen male Yucatan minipigs underwent balloon dilation of the right ureterovesical junction (UVJ) and lower ureter to twice its normal caliber. With the bladder open, bilateral upper tract dynamics measurements under different perfusion rates (0.5, 2, and 4 ml/min) were recorded predilation, immediately after dilation, and 1, 2, 3, 4, and 6 weeks after dilation.