Acquired dysfunction of CFTR underlies cystic fibrosis-like disease of the canine gallbladder.

Mucocele formation in dogs is a unique and enigmatic muco-obstructive disease of the gallbladder caused by the amassment of abnormal mucus that bears striking pathological similarity to cystic fibrosis. We investigated the role of cystic fibrosis transmembrane conductance regulatory protein (CFTR) in the pathogenesis of this disease. The location and frequency of disease-associated variants in the coding region of CFTR were compared using whole genome sequence data from 2,642 dogs representing breeds at low-risk, high-risk, or with confirmed disease.

Genetic analysis of basal stalk rot resistance introgressed from wild into cultivated sunflower ( L.) using an advanced backcross population.

Introduction: is a serious pathogen causing severe basal stalk rot (BSR) disease on cultivated sunflower ( L.) that leads to significant yield losses due to insufficient resistance. The wild annual sunflower species , commonly known as prairie sunflower is known for its resistance against this pathogen.

Microbiome analysis of bile from apparently healthy cats and cats with suspected hepatobiliary disease.

Background: Bacterial infection of bile is a common cause of hepatobiliary disease in cats. Whether bile harbors a core microbiota in health or in cases of suspected hepatobiliary disease in cats is unknown.

Objectives: Establish if gallbladder bile in apparently healthy cats harbors a core microbiota composed of bacterial taxa common to many individuals.

Introgression and targeting of the Pl and Pl genes for downy mildew resistance from wild Helianthus annuus and H. praecox into cultivated sunflower (Helianthus annuus L.).

Two new downy mildew resistance genes, Pl and Pl, were introgressed from wild sunflower species into cultivated sunflower and mapped to sunflower chromosomes 4 and 2, respectively Downy mildew (DM), caused by the oomycete pathogen Plasmopara halstedii (Farl.) Berl. & de Toni, is known as the most prevalent disease occurring in global sunflower production areas, especially in North America and Europe.