Publications by authors named "G Sciume"
Article Synopsis
- The micro-pipette aspiration technique is used to study the physical properties of fluids and biological materials, focusing on how fluids behave under varying suction pressures.
- A new mathematical model based on Cahn-Hilliard-Navier-Stokes equations is introduced to analyze the dynamics of cell aggregates in the aspiration-retraction process, taking into account different wetting conditions.
- The study offers insights into the implications of model assumptions on physical parameters and provides a new understanding of the action-reaction relationship between aspiration and retraction of cell aggregates.
Article Synopsis
- Microphysiological systems (MPSs) offer a promising alternative to animal models in drug development by reconstituting tissue interfaces and organ functions, although traditional materials like PDMS can interfere with drug testing accuracy.
- The GlioFlow3D platform combines 3D bioprinting and stereolithography to create hydrogel-based microchannels that better mimic human vasculature, integrating human cells and glioblastoma lines while using cost-effective materials and protocols to reduce cytotoxicity.
- This platform allows for improved drug testing accuracy, demonstrated through lower absorption of small molecules like Temozolomide, and reveals complex GBM drug resistance mechanisms influenced by the tissue microenvironment, enhancing potential for personalized therapy.
Article Synopsis
- * The study found that the transferrin receptor CD71 is increased in Tregs in liver cancer, and its deficiency caused severe health issues in mice due to impaired Treg expansion during early life.
- * CD71 deficiency led to iron overload in the liver, changes in gut microbiota, and suggests that Tregs may contribute to nutritional balance by competing for iron during early bacterial colonization.
Type 3 innate lymphoid cells (ILC3s) are key regulators of intestinal homeostasis and epithelial barrier integrity. In this issue of the JCI, Cao and colleagues found that a sensor of endoplasmic reticulum (ER) stress, the inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1) pathway, fine-tuned the functions of ILC3s. Activation of IRE1α and XBP1 in ILC3s limited intestinal inflammation in mice and correlated with the efficacy of ustekinumab, an IL-12/IL-23 blocker, in patients with Crohn's disease.
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