Publications by authors named "G Schultz"
The presence of microbial biofilms in many human chronic wounds led to the hypothesis that biofilms delay healing of these wounds. We tested this hypothesis in a population of 117 older individuals with venous leg ulcers who were receiving standardised therapy, including frequent debridement. Debridement specimens were analysed for the amount of bacterial biomass by two independent methods: a microscopic approach that scored the relative size and number of bacterial aggregates, interpreted as a biofilm metric, and conventional enumeration by agar plating for viable bacteria.
View Article and Find Full Text PDFBackground: Health insurance in the United States varies in coverage of essential diagnostic tests, therapies, and specialists. Health disparities between privately and publicly insured patients with MS have not been comprehensively assessed. The objective of this study is to evaluate the impact of public versus private insurance on longitudinal brain outcomes in MS.
View Article and Find Full Text PDFChronic wounds place a heavy burden on healthcare systems and markedly reduce the ability of patients to engage in activities of daily living. One major factor contributing to impaired wound healing is bacterial bioburden. With the rise in antibiotic resistance and the slowdown in antibiotic development pipelines, alternative antimicrobial strategies are important.
View Article and Find Full Text PDFObjective: The effect of continuous topical oxygen therapy (cTOT) on biofilm gene transcription profiles following inoculation onto porcine skin, using a customised molecular assay was determined.
Method: Sterilised porcine skin explants were inoculated with in triplicate: 0 hours as negative control; 24 hours cTOT device on; 24 hours cTOT device off. The oxygen delivery system of the cTOT device was applied to the inoculated tissue and covered with a semi-occlusive dressing.
Article Synopsis
- * Results show that different diets influenced specific gut bacterial taxa, with FOS increasing Fusicatenibacter and gluten increasing Eubacterium xylanophilum, but no significant changes in overall bacterial diversity or gut metabolites were observed.
- * Gastrointestinal symptoms after FOS consumption were not directly linked to notable shifts in the gut bacteria, although a reduction in Eubacterium (E. coprostanoligenes) was associated with increased gastrointestinal pain.