Publications by authors named "G Schuettfort"
Incidence of anal carcinoma (AC) in people living with HIV (PLWH) is increased compared to the general population. Adverse effects of chemoradiotherapy (CRT) on the immune system are associated with a significant detrimental prognosis on overall survival in patients receiving CRT for solid tumors. The aim of this study was to evaluate immunological factors, in particular the differences in recovery of CD4 and CD8 cell counts before and after CRT for AC in PLWH.
View Article and Find Full Text PDFPurpose: We aimed to review the landscape of late HIV diagnosis in Germany and discuss persisting and emerging barriers to earlier diagnosis alongside potential solutions.
Methods: We searched PubMed for studies informing the prevalence, trends, and factors associated with late HIV diagnosis in Germany. Author opinions were considered alongside relevant data.
Article Synopsis
- The study examined the impact of government-funded pre-exposure prophylaxis (PrEP) on sexually transmitted infections (STIs) among people living with HIV, specifically in men who have sex with men, after PrEP became covered by German health insurance in September 2019.
- Researchers enrolled 143 patients diagnosed with STIs over two groups: one year before and one year after PrEP coverage, noting an increase in STIs, particularly syphilis and chlamydia, in the latter group.
- The findings suggest a trend of rising STI rates among people living with HIV following the introduction of PrEP coverage, highlighting the need for increased discussions about STI risks between these overlapping communities.
Background: Over the past decade, antiretroviral therapy (ART) regimens that include integrase strand inhibitors (INSTIs) have become the most commonly used for people with HIV starting ART. Although trials and observational studies have compared virological failure on INSTI-based with other regimens, few data are available on mortality in people with HIV treated with INSTIs in routine care. Therefore, we compared all-cause mortality between different INSTI-based and non-INSTI-based regimens in adults with HIV starting ART from 2013 to 2018.
View Article and Find Full Text PDFBackground: HIV-infected patients with Pneumocystis-pneumonia (PCP) may develop paradoxical immune reconstitution inflammatory syndrome (IRIS), when combination antiretroviral therapy (cART) is started early during the course of PCP-treatment (PCPT). The aim of this study was to identify risk factors and predictors for PCP-IRIS and to improve individualized patient care.
Methods: An ICD-10 code hospital database query identified all Frankfurt HIV Cohort patients being diagnosed with PCP from January 2010 - June 2016.