Quantitative and qualitative analysis of in vivo Doppler signal enhancement of FS-069.

Rationale And Objectives: In vivo lifetime of ultrasound (US) contrast agents is still limited and thus a cause for ongoing investigations of new substances. The purpose of this study was to determine the time intensity changes of the Doppler signals obtained within the femoral vein after two different doses of a new microsphere-based ultrasound contrast agent.

Methods: Twenty-four healthy male volunteers (mean age, 29; average weight, 76 kg) were included in this study.