Publications by authors named "G Schilcher"
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly affecting critically ill ICU patients who lack traditional risk factors, complicating diagnosis due to histological evidence challenges.
- A study analyzed 202 patients across nine centers, comparing existing classification criteria (EORTC-MSG, FUNDICU, Asp-ICU) for diagnosing IPA and their effectiveness in identifying cases confirmed by histology.
- Findings revealed that EORTC-MSG was highly effective in patients with known risk factors, while the FUNDICU criteria's accuracy improved when including factors like ARDS and post-cardiac surgery complications, enhancing its predictive performance.
Extracorporeal membrane oxygenation (ECMO) is a life-saving technique used in critical care medicine for patients with severe respiratory or cardiac failure. This review examines the treatment and prophylaxis of fungal infections in ECMO patients, proposing specific regimens based on available data for different antifungals (azoles, echinocandins, amphotericin B/liposomal amphotericin B) and invasive fungal infections. Currently, isavuconazole and posaconazole have the most supported data, while modified dosages of isavuconazole are recommended in ECMO.
View Article and Find Full Text PDFObjectives: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a cytokine-driven inflammatory syndrome that is associated with substantial morbidity and mortality and frequently leads to ICU admission. Overall survival in adults with sHLH remains poor, especially in those requiring intensive care. Classical chemotherapeutic treatment exhibits myelosuppression and toxicity.
View Article and Find Full Text PDFIntroduction: Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BALF) may be helpful to differentiate between types of acute respiratory distress syndrome (ARDS) and may have potential for early detection of fungal infection.
Methods: We prospectively investigated levels of suPAR in BALF and serum in critically ill patients who underwent bronchoscopy for any reason at the ICU of the Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Article Synopsis
- In critically ill patients on ECMO, using a standard 200 mg loading dose of isavuconazole led to delayed target plasma concentrations.
- The study increased the initial loading dose to 300 mg and 400 mg for 15 patients to evaluate the effect on plasma levels.
- Results showed that a 400 mg loading dose significantly raised plasma concentrations to ≥1 mg/L within the first 24 hours without any adverse effects documented.