Publications by authors named "G Schalk"

Brain-computer interface (BCI) is a rapidly evolving technology that has the potential to widely influence research, clinical and recreational use. Non-invasive BCI approaches are particularly common as they can impact a large number of participants safely and at a relatively low cost. Where traditional non-invasive BCIs were used for simple computer cursor tasks, it is now increasingly common for these systems to control robotic devices for complex tasks that may be useful in daily life.

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Introduction: Stereoelectroencephalography (sEEG) is a mesoscale intracranial monitoring method which records from the brain volumetrically with depth electrodes. Implementation of sEEG in BCI has not been well-described across a diverse patient cohort.

Methods: Across eighteen subjects, channels with high frequency broadband (HFB, 65-115Hz) power increases during hand, tongue, or foot movements during a motor screening task were provided real-time feedback based on these HFB power changes to control a cursor on a screen.

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Article Synopsis
  • Primary hyperoxaluria (PH) is a rare genetic disorder affecting glyoxylate metabolism, and nedosiran is an FDA-approved RNAi therapeutic for treating PH1, evaluated in the PHYOX3 trial.
  • The trial analyzed the safety and efficacy of monthly nedosiran over 30 months in participants from a previous trial, with a focus on those with stable kidney function and no prior major interventions.
  • Results showed significant reductions in urinary oxalate levels and overall well-tolerance of the treatment, with most participants experiencing only mild to moderate adverse effects, and the study is still ongoing.
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Background: Intracranial electrodes are typically localized from post-implantation CT artifacts. Automatic algorithms localizing low signal-to-noise ratio artifacts and high-density electrode arrays are missing. Additionally, implantation of grids/strips introduces brain deformations, resulting in registration errors when fusing post-implantation CT and pre-implantation MR images.

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