Reliability of core needle biopsy for HER2-low early-stage breast cancer.

Background: The reliability of core needle biopsy (CNB) for HER2-positive breast cancer is well established. However, data on HER2-low and the potential for inconsistencies with surgical samples are limited.

Materials And Methods: Concordance between CNB and surgical samples was assessed using the unweighted Cohen kappa statistic (Kc) in a consecutive series of 776 treatment-naïve early-stage breast cancer patients.

Impact of an artificial intelligence decision support system among radiologists with different levels of experience in breast ultrasound: A prospective study in a tertiary center.

Purpose: To assess the impact of an artificial intelligence decision support system (Koios DS) on the diagnostic performance of radiologists with different experience in breast ultrasound and to evaluate its potential to reduce unnecessary biopsies.

Methods: This observational, prospective, single-centre study included consecutive patients scheduled for ultrasound-guided core-needle biopsy of suspicious breast lesions. Three radiologists with different experience in breast ultrasound (senior breast radiologist: 20 years; junior breast radiologist: 3 years; general radiologist: less than 1 year) independently evaluated the lesions, assigning BI-RADS categories before and after Koios DS application.

Preoperative breast MRI reduces reoperations for unilateral invasive lobular carcinoma: a patient-matched analysis from the MIPA study.

Objectives: To investigate the surgical impact of preoperative breast MRI in patients diagnosed with invasive lobular breast cancer (ILC) in a prospective observational study.

Methods: The prospective MIPA observational study database was queried for patients aged 18-80 with newly diagnosed unilateral ILC at needle biopsy referred for primary surgery. Patients who underwent preoperative MRI (MRI group) were matched (1:1) with those who did not (noMRI group) according to nine confounding covariates.

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients.

In preclinical experiments, cyclic fasting-mimicking diets (FMDs) showed broad anticancer effects in combination with chemotherapy. Among different tumor types, triple-negative breast cancer (TNBC) is exquisitely sensitive to FMD. However, the antitumor activity and efficacy of cyclic FMD in TNBC patients remain unclear.

Diagnostic performance of MRI-guided vacuum-assisted breast biopsy (VABB): an essential but still underused technique.

Background: Magnetic resonance imaging (MRI)-guided vacuum-assisted breast biopsy (VABB) is an increasingly requested procedure, but it implies training and experience both in its execution and in determining radiological-pathological concordance and is therefore performed in dedicated breast centers. The purpose of this study is to evaluate the diagnostic performance of MRI-guided vacuum-assisted biopsy and to determine the upgrade rate after surgery or follow-up.

Methods: We retrospectively evaluated all consecutive patients with suspicious MRI findings without corresponding mammographic and ultrasonographic findings who underwent MRI-guided vacuum-assisted breast biopsy (VABB) at our Institution from November 2020 to March 2023.