Publications by authors named "G Scabia"
Article Synopsis
- - The study investigates the relationship between SARS-CoV-2 infection and adipocytes (fat cells) using the SGBS human cell line, highlighting that excess fat mass may increase the risk of severe COVID-19.
- - Findings show that adipocytes can be infected by SARS-CoV-2, leading to the release of viral particles and significant changes in cell structure and function, such as increased inflammation and altered lipid metabolism.
- - The research concludes that SARS-CoV-2 infection causes notable morphological and functional modifications in adipocytes, possibly affecting the progression and severity of COVID-19.
Article Synopsis
- * A study examined the abundance of circulating microRNAs (cmiRs-320) in LD patients and found that certain cmiRs are significantly upregulated or downregulated, especially in severe forms of LD.
- * The results suggest that cmiRs-320 could serve as new biomarkers for LD, with significant relationships between specific cmiRs and metabolic indicators, hinting at potential mechanisms behind WAT dysfunction.
A deterioration in cognitive performance accompanies brain aging, even in the absence of neurodegenerative pathologies. However, the rate of cognitive decline can be slowed down by enhanced cognitive and sensorimotor stimulation protocols, such as environmental enrichment (EE). Understanding how EE exerts its beneficial effects on the aged brain pathophysiology can help in identifying new therapeutic targets.
View Article and Find Full Text PDFBerardinelli-Seip congenital lipoatrophy (BSCL) is characterized by near total fat atrophy, associated with the progressive development of metabolic complications. BSCL type 1 (BSCL1) is caused by mutations in , encoding 1-acylglycerol-3phosphate-O-acyltransferase β (recently renamed lysophosphatidic acid acyltransferase beta), which catalyzes the transformation of lysophosphatidic acid in phosphatidic acid, the precursor of glycerophospholipids and triglycerides. BSCL1 is an autosomal recessive disease due to pathogenic variants leading to a depletion of triglycerides inside the adipose organ, and to a defective signaling of key elements involved in proper adipogenesis.
View Article and Find Full Text PDFPurpose: The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of obese patients. This study aims to test the ability of a selective synthetic α7nAChR agonist, the spirocyclic Δ-isoxazoline derivative (R)-(-)-ICH3 (ICH3), to counteract acute inflammation and obesity-associated modifications in WAT.
Methods: We employed the LPS-septic shock murine model, human primary adipocytes and diet-induced obese (DIO) mice.