The Frequency and Potential Implications of HFE Genetic Variants in Children With Cystic Fibrosis.

Background: Genetic modifiers have been identified that increase the risks of lung disease and other complications, such as diabetes in people with cystic fibrosis (CF). Variants in the hemochromatosis gene (HFE) were reported in a study of adults to be associated with worse lung disease.

Objectives: To ascertain the frequency of HFE variants, particularly C282Y (c.

Predictive control of musculotendon loads across fast and slow-twitch muscles in a simulated system with parallel actuation.

Research in lower limb wearable robotic control has largely focused on reducing the metabolic cost of walking or compensating for a portion of the biological joint torque, for example, by applying support proportional to estimated biological joint torques. However, due to different musculotendon unit (MTU) contractile speed properties, less attention has been given to the development of wearable robotic controllers that can steer MTU dynamics directly. Therefore, closed-loop control of MTU dynamics needs to be robust across fiber phenotypes, that is ranging from slow type I to fast type IIx in humans.

Dynamic Duo: Design and Validation of an Autonomous Frontal and Sagittal Actuating Hip Exoskeleton for Balance Modulation During Perturbed Locomotion.

Humans are required to maintain balance during locomotion in challenging environments, which present an even bigger challenge for individuals with balance impairments. Exoskeleton-driven balance augmentation is a promising avenue to assist users in these environments, but there has been little work in developing exoskeleton devices for these applications. In this work, we present the design, realization, and validation of an autonomous robotic hip exoskeleton with frontal and sagittal actuation.

Acceptability of Telehealth Post-Pandemic Among Clinicians Across the United States Caring for People With Cystic Fibrosis.

Background: The COVID-19 pandemic ushered widespread adoption of telehealth (TH) by cystic fibrosis (CF) centers in the USA. TH was initially described as well-accepted by both clinicians and patients. As we move past the unusual circumstances of the pandemic, the sustainability of TH remains untested.

Male sexual and reproductive health in cystic fibrosis: A concept mapping study.

Background: Males with cystic fibrosis (MwCF) face general and disease-specific sexual and reproductive health (SRH) concerns. Using concept mapping (CM), this study identified the SRH topics valued by members of the CF community.

Methods: MwCF 18 years and older, parents and partners of MwCF, and healthcare providers participated in an online CM study.