Regimens and Response Assessment in Minimally Invasive Image-Guided Therapies for Vascular Malformations: Insights from a Large Cohort Study at a Tertiary-Care Hospital.

This retrospective study was aimed at characterizing vascular malformations (VMFs) presenting for minimally invasive image-guided therapies (MIT) at a tertiary-care center and evaluating treatment regimens and image-based outcomes using MRI. We analyzed demographic, disease-related, and radiologic features of VMFs presenting to interventional radiology between May 2008 and August 2020 using compendium vascular anomaly (Compva) criteria. MIT and specific agents were evaluated, and treatment effects were assessed through volumetry and mean signal intensity (MSI) on multiparametric longitudinal MRI.

Neoadjuvant treatment of pancreatic ductal adenocarcinoma: Whom, when and how.

Pancreatic ductal adenocarcinoma (PDAC), which is notorious for its aggressiveness and poor prognosis, remains an area of great unmet medical need, with a 5-year survival rate of 10% - the lowest of all solid tumours. At diagnosis, only 20% of patients have resectable pancreatic cancer (RPC) or borderline RPC (BRPC) disease, while 80% of patients have unresectable tumours that are locally advanced pancreatic cancer (LAPC) or have distant metastases. Nearly 60% of patients who undergo upfront surgery for RPC are unable to receive adequate adjuvant chemotherapy (CHT) because of postoperative complications and early cancer recurrence.

International comparison: Spinal cord injury in the USA and UK.

Background: Long-term survival after spinal cord injury (SCI) has been extensively studied in the US and UK.

Objective: To compare SCI epidemiology and survival results between the US and UK for the same time period and patient groups.

Methods: We restricted attention to persons injured at ages 18 and older who had survived at least 2 years post injury and were not ventilator dependent.

Digital Image Decoder for Efficient Hardware Implementation.

Increasing the resolution of digital images and the frame rate of video sequences leads to an increase in the amount of required logical and memory resources necessary for digital image and video decompression. Therefore, the development of new hardware architectures for digital image decoder with a reduced amount of utilized logical and memory resources become a necessity. In this paper, a digital image decoder for efficient hardware implementation, has been presented.

MMP-9/BDNF ratio predicts more severe COVID-19 outcomes.

COVID-19 clinically manifests from asymptomatic to the critical range. Immune response provokes the pro-inflammatory interactions, which lead to the cytokines, reactive oxygen/nitrogen species, peptidases, and arachidonic acid metabolites enlargement and activation of coagulation components. Matrix metalloproteinases (MMPs) contribute to tissue destruction in the development of COVID-19.