Publications by authors named "G Sarangi"

Article Synopsis
  • Selenocysteine, a unique selenium-containing amino acid, is critical for the function of certain enzymes called selenoprotein oxidoreductases but has been lost in some mammalian lineages, particularly in glutathione peroxidase 6 (GPX6).
  • The loss of selenocysteine in GPX6 occurred through strong evolutionary changes while also introducing new mutations that altered the enzyme's catalytic properties.
  • This case of adaptive convergence suggests that these modifications led to novel enzymatic functions rather than merely compensating for the loss of selenocysteine, highlighting an interesting aspect of evolution in mammalian selenoproteins.
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Background: Ventilator-associated pneumonia (VAP) is the most frequent intensive care unit (ICU)-acquired infection. The etiology of VAP and their antimicrobial susceptibility pattern varies with different patient populations and types of ICUs.

Materials And Methods: An observational cross-sectional study was performed over a period of 2 years in a tertiary care hospital to determine the various etiological agents causing VAP and to detect the presence of multidrug-resistant (MDR) pathogens in these VAP patients.

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Selenium (Se), a sparse element on earth, is an essential micronutrient in the vertebrate diet and its intake depends on its content in soils and waters worldwide. Selenium is required due to its function in selenoproteins, which contain selenocysteine (Sec), the 21st amino acid in the genetic code, as one of their constituent residues. Selenocysteine is analogous to the amino acid cysteine (Cys), which uses the abounding element sulfur instead.

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Cerebrospinal fluid (CSF) within the cerebral ventricular system is secreted by a neuroepithelial tissue which is called as the choroid plexus. Tumors arising from these tissues are rare. Choroid plexus papillomas (CPPs) have been denoted as WHO grade I of the choroid plexus tumors.

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