Publications by authors named "G Santandrea"
The advent of "omics" technologies for high-depth tumor profiling has provided new information regarding cancer heterogeneity. However, a bulk omics profile can only partially reproduce tumor complexity, and it does not meet the preferences of pathologists used to perform an in situ assessment of marker expression, for instance, with immunohistochemistry. The NanoString GeoMx® Digital Spatial Profiler (DSP) is a platform for morphology-guided multiplex profiling of tissue slides, which allows the digital quantification of target analytes in different neoplastic settings.
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- - IAIs (intra-abdominal infections) are a leading cause of serious illness and death, especially in sepsis cases, with high hospital mortality rates (23-38%); timely identification and treatment are essential for better outcomes.
- - Effective management involves source control, which includes various procedures such as surgery, drainage, and debridement to remove the infection source and restore function, alongside early clinical evaluation and the use of prognostic scores to assess severity.
- - Rising antibiotic resistance poses a major global health challenge, highlighting the importance of appropriate antibiotic use, infection control measures, and adherence to guidelines in surgical departments to improve patient outcomes.
Long non-coding RNAs (lncRNAs) are transcripts without coding potential that are pervasively expressed from the genome and have been increasingly reported to play crucial roles in all aspects of cell biology. They have been also heavily implicated in cancer development and progression, with both oncogenic and tumor suppressor functions. In this work, we identified and characterized a novel lncRNA, TAZ-AS202, expressed from the TAZ genomic locus and exerting pro-oncogenic functions in non-small cell lung cancer.
View Article and Find Full Text PDFNeoadjuvant chemotherapy (NAC) alone or combined with target therapies represents the standard of care for localized triple-negative breast cancer (TNBC). However, only a fraction of patients have a response, necessitating better understanding of the complex elements in the TNBC ecosystem that establish continuous and multidimensional interactions. Resolving such complexity requires new spatially-defined approaches.
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